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谈论安慰剂:对患者对开放式安慰剂在临床实践中的实施态度的定性研究

Antje Frey Nascimento¹, Berfin Bakis¹, Jens Gaab¹

¹Division of Clinical Psychology and Psychotherapy, Faculty of Psychology, University of Basel, Basel, Switzerland.

Frontiers in psychology

|August 18, 2025

概括

开放标签安慰剂 (OLP) 显示出在伦理上利用安慰剂效应的希望. 患者对OLP的态度各不相同,对信任和实际实施的担忧需要进一步探索,以获得成功的临床整合.

科学领域:

医学伦理医学伦理
精神病体医学是一种精神病体医学.
临床心理学临床心理学

背景情况:

开放标签安慰剂 (OLP) 证明了有效性和安全性,与利用安慰剂效应的伦理原则保持一致.
患者的接受和观点对于将OLP等新型干预措施实施到临床实践中至关重要.
定性研究对于了解患者的态度,感知障碍和OLP的好处至关重要.

研究的目的:

调查患者的态度,担忧和关于开放标签安慰剂 (OLP) 临床实施的想法.
探索患者对OLP干预措施在医疗机构的可行性和接受性的观点.
确定将OLP纳入常规临床实践的潜在障碍和促进者.

主要方法:

进行了三次在线焦点小组讨论 (FGDs) 与患有慢性背痛,慢性偏头痛或化疗诱导的恶心的成年患者.
在数据分析的社会构造主义框架内,利用了带有诱导-演的混合方法的反思性主题分析.
从瑞士巴塞尔大学医院的门诊诊所招募了参与者.

主要成果:

确定了五个关键主题:"安慰剂:有希望但有风险"",OLP的接受取决于无数"",值得信赖,但欺骗可能是必要的"",在没有安慰剂的情况下利用安慰剂效应"和"从长椅到床边:OLP的临床转移".
揭示了患者的不同态度,不同程度的接受,并对OLP使用的伦理和实际方面表示担忧.
突出了关于 OLP 实施,前提条件和医疗保健提供者的作用的矛盾.

结论:

患者和公众的参与对于OLP干预措施的成功实施至关重要.
对于OLP及其实际应用的态度在患者群体之间甚至在相同的临床条件内都存在差异.
解决伦理考虑和实际挑战对于在临床实践中广泛采用OLP至关重要.

关键词:

他们的态度和态度.焦点小组是一个重点小组.开放的安慰剂安慰剂.患者患者患者患者患者患者患者患者和公众参与.定性研究是指质量研究.

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