构建自组装基基/纳米粒子用于癌症治疗的先进策略
Jintao Pan1, Yun Zeng1,2, Syeda Samar Mustafa1,3
1State Key Laboratory of Vaccines for Infectious Diseases, Xiang'an Biomedicine Laboratory, Fujian Engineering Research Center of Molecular Theranostic Technology, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Small (Weinheim an der Bergstrasse, Germany)
|August 18, 2025
概括
这篇评论探讨了用于癌症治疗的基,详细介绍了制造纳米纤维,纳米和纳米粒子的方法. 超临界二氧化碳为这些先进的药物输送系统提供了一种新的灭菌解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 类水凝具有多孔结构,生物相容性和易于用于生物医学应用的功能.
- 它们是开发先进药物输送系统的有希望的支架,特别是用于癌症治疗.
研究的目的:
- 审查产生抗癌基纳米结构的触发方法.
- 探索使用超临界二氧化碳用于水凝灭菌的方法.
主要方法:
- 总结了各种触发方法:加热-冷却,溶剂切换,离子强度,度,超声波,pH,光交联和液体-液体相分离.
- 讨论了线性和循环的纳入自组装纳米结构的方法.
- 突出了超临界二氧化碳作为绝育技术.
主要成果:
- 多种方法使得基于的纳米纤维,纳米水凝和纳米粒子 (NP) 的形成成为可能.
- 线性和循环可以用于各种自组装结构.
- 超临界二氧化碳为水凝灭菌提供了一种温和,无残留的方法.
结论:
- 类水凝是抗癌纳米药物开发的多功能平台.
- 一系列的刺激反应方法促进了量身定制的纳米结构的创建.
- 超临界二氧化碳提供了一个可行的解决方案,可以在不损害结构或功能的情况下消毒酸.
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There are several types of targeted therapies against specific...
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