奖励回路的异常功能连接模式与第一发精神分裂症的负面症状和认知功能有关
Yunyi Han1,2, Fuchun Zhou1, Xue Yang2
1The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China.
Psychiatry and clinical psychopharmacology
|August 18, 2025
概括
第一发精神分裂症患者表现出大脑奖励回路连接的改变,与负面症状有关. 奖励网络中的增强连接可能有助于这些症状,而认知功能在患者和健康对照人群中显示出不同的相关性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症与大脑电路中断有关.
- 奖励回路在激励和情绪调节中起着至关重要的作用.
- 了解第一发精神分裂症 (FES) 的功能连接 (FC) 对早期干预至关重要.
研究的目的:
- 研究大脑奖励回路中的异常功能连接 (FC) 与FES中负面症状之间的关系.
- 检查奖励回路FC与FES认知障碍之间的关联.
- 为了将FES患者的FC模式与健康对照 (HC) 进行比较.
主要方法:
- 这是一项涉及52名FES患者和59名HC患者的横截面研究.
- 分析了13个预定义的奖励电路感兴趣区域 (ROI) 中的FC及其与整个大脑的连接.
- 使用 MATRICS 共识认知电池进行认知功能评估.
主要成果:
- 在FES患者中,左腹侧前额皮层和左丘脑之间增加了FCs,与负面症状负面相关.
- 整个大脑的分析显示,与HC相比,FES患者中广泛存在弱化的FCs.
- 在HC患者中,特定的FC与注意力/警觉性和学习有正相关,但在FES患者中没有,这表明脱.
结论:
- 在奖励回路中加强网络内部的FC可能会导致FES的负面症状.
- 与HC相比,FES患者的改变FC模式表明了与HC相比明显的神经特征.
- 奖励回路与认知控制区域的脱可能解释FES的认知缺陷.
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