在微生物组研究中分享FAIR序列数据和元数据的层级标准
Lina Kim1, Anton Lavrinienko1, Zuzana Sebechlebska1
1Department of Health Sciences and Technology, ETH Zurich, 8092 Zurich, Switzerland.
Nucleic acids research
|August 18, 2025
概括
微生物组研究面临着数据共享和元数据标准化的挑战. 一个新的章系统和自动化工具显示,许多研究缺乏足够的数据可用性和一致的元数据,阻碍了可重复性.
科学领域:
- 生命科学 生命科学
- 微生物组研究的研究.
- 生物信息学是一种生物信息学.
背景情况:
- 微生物组研究正在迅速扩大,并且严重依赖数据.
- 现有的共享微生物组序列数据和元数据的政策存在,但遵守是不一致的.
- 标准化元数据对于协调和比较跨研究数据至关重要.
研究的目的:
- 为评估微生物组研究中的数据/元数据共享合规性提出一个分层章系统.
- 开发一种自动化工具,用于评估出版物是否遵守数据报告标准.
- 促进微生物组社区内的开放研究数据最佳实践.
主要方法:
- 开发了一个双层章系统来评估数据和元数据共享.
- 创建了一个自动化工具来评估对安普利康和元基因组序列数据的报告标准.
- 系统评估了2929篇关于人类肠道微生物组研究的出版物和370篇关于土壤和肠道微生物组的案例研究.
主要成果:
- 几乎一半的评估出版物未能满足序列数据可用性的最低标准.
- 不一致的元数据报告对数据协调和跨研究比较构成重大障碍.
- 该研究发现了当前数据可用性声明的无效性和缺乏标准化元数据.
结论:
- 需要改进实践和基础设施,以降低提交数据的障碍,并提高微生物组研究的可复制性.
- 拟议的分层标签框架旨在鼓励讨论数据共享,并促进数据的再利用.
- 采用章系统可以支持微生物科学中的可查找,可访问,可互操作和可重复使用 (FAIR) 数据原则.
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