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粮食不安全是阿尔茨海默病的重要危险因素:一项案例对照研究
Mohammad Mehdi Abbasi1,2, Mahdyeh Karimi1, Sajjad Khandae1,2
1Department and Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of research in health sciences
|August 18, 2025
概括
粮食不安全与阿尔茨海默病 (AD) 的更高风险有关. 这种关联在不同年龄组中观察到,在女性中尤为明显.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在了解粮食不安全与阿尔茨海默病 (AD) 风险之间的联系方面存在重大差距.
- 这项研究通过调查潜在的关联来解决这一差距.
研究的目的:
- 评估粮食不安全与患阿尔茨海默病 (AD) 的风险之间的关联.
主要方法:
- 一项涉及301名参与者的病例控制研究 (150例AD病例,151例对照).
- 食品安全状况的评估是使用USDA家庭食品安全问卷的经过验证的波斯语翻译.
- 参与者从德黑兰的卫生中心招募.
主要成果:
- 在调整了混杂因素后,粮食不安全与阿尔茨海默病风险增加显著相关 (OR: 2.80,95% CI: 1.59-4.94).
- 这种关联在女性参与者中更强烈 (OR:3.54,95% CI:1.72-7.30).
- 65岁以下的食物不安全的人患阿尔茨海默症的可能性增加了近四倍 (OR:3.94,95% CI:1.48-10.47),而65岁以上的人患阿尔茨海默症的可能性增加了2.89倍 (OR:2.89,95% CI:1.36-6.14).
结论:
- 粮食不安全可能是导致阿尔茨海默病风险增加的一个因素.
- 建议进行进一步的前性研究,以探索这种关系及其与其他神经疾病的潜在联系.
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