尿路生物标志物作为儿童尿病的预测因素:系统性审查和元分析
Derryl Texaga1, Saskia Ratna Desita2, Nadira Muthi Tsania3
1Faculty of Medicine, Airlangga University, Surabaya. derilteksaga@gmail.com.
概括
尿中酸盐,氧酸盐和水平可以帮助预测儿科尿病风险. 低酸盐,高酸盐和高是儿童石头形成的关键指标.
科学领域:
- 儿科脏病学 儿科脏病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物标志物发现发现
背景情况:
- 儿科尿病对功能和生活质量构成长期风险.
- 以前对小儿尿病风险的尿路生物标志物的研究已经产生了不一致的结果.
- 本元分析评估了儿童尿路风险因素的诊断潜力.
研究的目的:
- 在儿科尿病中,评估尿酸/肌素 (Cit/Cr),氧酸盐/肌素 (Ox/Cr),/肌素 (Ca/Cr),/肌素 (P/Cr),/肌素 (Mg/Cr) 和尿素/肌素 (Ur/Cr) 的尿酸比率的诊断价值.
- 确定可靠的尿路生物标志物,用于预测儿童尿病风险.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 包括6项研究 (1队列,5例对照) 涉及2060名儿科患者.
- 尿路风险因素的分析和标准平均差异 (SMD) 的计算与异质性评估.
主要成果:
- 在患有尿病和没有尿病的儿童之间观察到Cit/Cr,Ca/Cr,Ox/Cr和Mg/Cr比率的显著差异.
- 低度尿 (Cit/Cr),高度尿 (Ox/Cr),高度尿 (Ca/Cr) 和低度尿 (Mg/Cr) 与儿科尿病有显著的相关性.
- 对于P/Cr和Ur/Cr比率没有发现显著的关联.
结论:
- /Cr,氧/Cr和Ca/Cr比率显示出作为小儿尿病风险的尿路生物标志物具有前途.
- 低酸性尿症,高酸性尿症和高酸性尿症是关键的代谢异常,与儿童尿路结石形成有关.
- 需要使用标准化方法进行进一步的研究,以证实研究结果并指导临床实践.
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