在接受17-interleukin抑制剂的银病患者中,不良事件和免疫反应
Christopher Willy Schwarz1, Charlotte Näslund-Koch2, Claus Zachariae3
1Department of Dermatology and Allergy, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. christopher.willy.schwarz.01@regionh.dk.
Acta dermato-venereologica
|August 18, 2025
概括
在开始使用介素-17 抑制剂之前,对口腔Candida albicans殖民的查可以预测和预防口腔角膜炎. 这种主动的方法有助于管理正在接受治疗的牛皮患者的感染.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 微生物学 微生物学
背景情况:
- 干白素-17 (IL-17) 抑制剂是有效的牛皮治疗方法,但会增加感染风险,特别是口服候选症.
- 确定IL-17抑制剂不良事件的预测标记对于患者安全至关重要.
研究的目的:
- 在接受IL-17抑制剂治疗的患者中确定感染和炎症性肠病爆发的预测标志物.
- 描述IL-17抑制剂治疗期间的功能性免疫反应.
主要方法:
- 使用全血刺激系统 (TruCulture®) 来分析免疫反应.
- 接受IL-17抑制剂 (n=36) 或阿达利穆马布 (n=24) 的牛皮患者在52周内进行了监测.
- 在基线,第12周和第52周采集了样本 (抽样,血液,便).
主要成果:
- 基线口服Candida albicans殖民预测IL-17抑制剂治疗期间口服候选症风险增加.
- 在Adalimumab组中没有发生口腔候群病例.
- 肠道炎症 (便calprotectin) 和金黄色葡萄球菌殖民情况保持稳定.
- 与阿达利木马布相比,IL-17抑制剂诱导了抗炎状态,并增强了TLR3介导的抗病毒反应.
结论:
- 在IL-17抑制剂启动之前对口服Candida albicans殖民的查是一种有价值的风险分层和早期干预策略.
- 了解免疫反应可以优化IL-17抑制剂在牛皮管理中的使用.
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