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一种无载体纳米光敏剂用于红光激活的NO释放和组合疗法

Chaonan Li1, Huixuan Qi2, Jinjun Jia3

  • 1School of Environment and Biological Engineering, Wuhan Technology and Business University, Hongshan District, Wuhan 430065, China.

Organic & biomolecular chemistry
|August 18, 2025
PubMed
概括

研究人员开发了新的纳米粒子,可以在需要时使用红光释放氧化 (NO) 和单片氧. 这一突破使得精确的结合性癌症治疗能够通过控制NO的输送来改善治疗结果.

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Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
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