在多中心肺癌研究中的基于PET的放射性分析以及特征域协调的影响
Pooja Dwivedi1,2,3, Sagar Barage4, Rajshri Singh2
1Department of Nuclear Medicine and Molecular Imaging, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, 410210, India.
Physical and engineering sciences in medicine
|August 18, 2025
概括
协调方法提高AI辅助的肺癌亚型分类使用18F-FDG PET放射学. 康巴特显著提高了模型性能,将AUC从0.556提高到0.996以区分腺癌和状细胞癌.
科学领域:
- 医疗成像医学成像
- 人工智能的人工智能
- 在瘤学瘤学.
背景情况:
- 放射性生物标志物为精准医学提供了对瘤生物学的非侵入性见解.
- 放射学的临床翻译受到多中心研究标准化问题 (扫描器变异,协议) 的挑战.
研究的目的:
- 通过机器学习评估协调方法对多中心18F-FDG PET放射学对肺癌组织学亚型分类的影响.
- 为了比较Z-Score,Quantile和ComBat协调技术.
主要方法:
- 从三个中心对178例肺癌 (腺癌,状细胞癌) 病例进行了回顾性分析.
- 在3D ROI细分后从18F-FDG PET图像中提取111个放射性特征.
- 应用Z-Score,Quantile和ComBat协调;通过递归特征消除进行特征选择;极端梯度增强模型训练和验证.
主要成果:
- 协调方法改变了放射性特征的分布和选择.
- 亚型分类的曲线下的面积 (AUC) 从0.556 (不协调) 提高到0.719 (Z-Score),0.952 (量子) 和0.996 (ComBat).
- 在增强人工智能辅助PET放射学用于肺癌分类方面,ComBat表现出卓越的性能.
结论:
- 数据协调对于强大的多中心放射学研究至关重要.
- 基于PET放射学,ComBat方法显著提高了机器学习模型在分类基于PET放射学的肺癌组织学亚型的性能.
- 通过ComBat进行标准化,便于可靠的AI驱动的瘤临床应用.
相关概念视频
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
01:13Radiological Investigation III: Pulmonary Angiogram and PET Scan
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
01:25Imaging Studies II: Positron Emission Tomography and Scintigraphy
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET