相关实验视频

Updated: Sep 11, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

慢性病和抑郁症之间的关联:来自NHANES 2015-2018年和门德尔随机化分析的证据

Xi Cheng¹, Xiting Cai¹, Jinzhao Ma¹

¹Center of Reproductive Medicine, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University. No.305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu, China.

Clinical and experimental nephrology

|August 18, 2025

概括

慢性病 (CKD) 显著增加抑郁症的风险. 这项研究证实了因果关系,强调了针对CKD患者进行有针对性的干预措施以管理心理健康的必要性.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
精神病学是一个精神病学.
流行病学流行病学

背景情况:

在慢性病 (CKD) 和抑郁症之间存在着已知的关联.
慢性病对抑郁风险的因果关系和具体影响需要进一步研究.

研究的目的:

探索慢性病 (CKD) 和抑郁症之间的因果关系.
确定CKD如何影响患抑郁症的风险.

主要方法:

利用了来自7537名国家健康和营养检查调查 (NHANES) 参与者的数据,使用患者健康问卷9 (PHQ-9) 分类.
使用加权多变量/分层物流回归和接收器运行特征 (ROC) 分析来评估关联和预测价值.
使用孟德尔随机化 (MR) 分析证实了因果关系.

主要成果:

在多重回归模型 (OR > 1, p < 0.05) 中,慢性病 (CKD) 被确定为抑郁症的重要危险因素.
尽管控制了年龄和性别等共变量,但该协会仍然很强大.
经过ROC分析,CKD对抑郁风险的预测效果显著 (AUC=0.818).
门德尔的随机分析证实了CKD和抑郁症之间的积极因果关系 (OR = 1.002,p < 0.05).

结论:

慢性病 (CKD) 是导致抑郁症风险增加的一个因素.
这些发现强调了对患有CKD的个人抑郁症采取主动和有针对性的干预措施的必要性.

关键词:

慢性脏疾病慢性脏疾病抑郁症抑郁症抑郁症门德尔的随机化尼汉斯 (NHANES) 是一个名人.

更多相关视频

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

相关概念视频

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Depressive Disorders: Etiology

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Chronic Kidney Disease III: Interprofessional Care

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

Stress and Mental Health

Stress and Mental Health

Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...

Chronic Kidney Disease IV: Nursing Management

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...