台万通过调节APP/PS1小鼠的Nrf2/ARE/HO-1信号通路来改善认知障碍
Xin-Chen Wang1,2, Guang-Liang Wu3,4, Hai-Yan Cai5
1Department of Pharmaceutical Engineering, College of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, China.
Neurochemical research
|August 18, 2025
概括
传统中医药Jiao Tai Wan (JTW) 改善了阿尔茨海默氏症患者的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,影响记忆,智力和行为.
- 众所周知,Jiao Tai Wan (JTW) 是Coptis chinensis和肉 (10:1比率) 的配方,可以促进认知功能.
- 在JTW的认知效益背后的精确机制需要进行系统的调查.
研究的目的:
- 对阿尔茨海默病的小鼠模型 (APP/PS1小鼠) 中的认知缺陷的Jiao Tai Wan (JTW) 的治疗效果和潜在机制进行调查.
- 评估JTW对神经退行,粉样,胆系统,炎症,氧化应激以及Nrf2/ARE/HO-1通路的影响.
主要方法:
- 行为测试 (莫里斯水迷宫,Y迷宫) 评估认知和空间学习能力.
- 采用了分子技术,包括PCR,ELISA,Nissl染色和西方涂抹.
- 分析包括神经变因子 (BDNF,NGF),突触蛋白 (SYP),粉样蛋白-β (Aβ) 水平,分泌酶活动,胆固醇标记物 (Ach,AchE,ChAT),炎症因子,氧化应激指标和Nrf2/ARE/HO-1通路.
主要成果:
- 在APP/PS1小鼠中,JTW显著改善了学习,记忆和空间探索.
- 治疗JTW改善了神经退行性病变,减少了大脑粉症,并增强了胆固醇神经系统.
- JTW抑制了炎症因素和氧化应激,特别是调节了Nrf2/ARE/HO-1通路.
结论:
- 泰旺 (JTW) 在小鼠模型中显示出对阿尔茨海默氏症病理学的显著神经保护作用.
- JTW通过调节Nrf2/ARE/HO-1通路来增强认知功能,增加神经营养因子,减少神经炎症和氧化应激.
- 这些发现支持JTW作为阿尔茨海默病的潜在治疗药物,需要进一步的临床研究.
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