皮肤状细胞癌的响应适应性瘤手术:在新辅助免疫疗法之后的范式转变
Dan Yaniv1, Shorook Naara1, Frederico Omar Gleber Netto1
1Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Annals of surgical oncology
|August 18, 2025
概括
针对皮肤状细胞癌 (CSCC) 的新辅助塞米普利马布后的响应适应性瘤手术 (RAOS) 显示了与标准切除相似的生存结果. 此外,RAOS还降低了手术发病率,为CSCC治疗提供了一个安全的替代方案.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 免疫治疗是一种免疫疗法.
背景情况:
- 新辅助剂塞米普利马布在皮肤状细胞癌 (CSCC) 中显示出显著的病理反应.
- 评估响应适应性瘤手术 (RAOS) 作为标准切除的替代方案,对于降低手术发病率至关重要.
- 评估RAOS与新辅助药CEMIPLIMAB一起用于CSCC治疗是有必要的.
研究的目的:
- 确定RAOS是否可以降低接受新辅助药CEMIPLIMAB治疗的CSCC患者的手术致病率.
- 与标准切除相比,保持瘤安全性和相似的生存结果.
- 探索RAOS作为CSCC的可行的替代手术方法.
主要方法:
- 对41名头部和部CSCC患者 (2018-2021) 的回顾性队列研究.
- 患者接受了新辅助剂塞米普利马布,随后进行RAOS或标准切除.
- 结果包括手术边缘,无复发生存率,器官保存和重建需求.
主要成果:
- 17名患者接受了RAOS,24名患者进行了标准切除.
- 在24%的患者中,RAOS导致了器官的保存,并且在24%的患者中避免了自由重建.
- 两组都实现了明显利率高 (RAOS 94%,标准92%) 和类似的2年地方区域无复发生存率 (RAOS 95%,标准90%).
结论:
- 在新辅助剂塞米普利马布 (cemiplimab) 之后的RAOS对CSCC是瘤安全的.
- RAOS显示了与标准切除相似的生存结果,手术致病率降低.
- 建议进行进一步的前性研究,以验证这些研究结果对CSCC治疗的有效性.
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