绘制T细胞枯竭的研究现状和新兴前沿:一项基于数据挖掘的综合性研究
Pengcheng Li1, Qiang Guo2, Yanfeng Gao3
1Department of Burn and Plastic Surgery, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Annals of surgical oncology
|August 18, 2025
概括
本文档分析了从2005年至2024年的T细胞耗尽 (Tex) 研究,揭示了指数增长和免疫疗法和CAR T细胞疗法等关键领域. 它强调美国和中国是主要的贡献者,哈佛大学是顶级机构,确定未来的研究热点.
科学领域:
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
- 在瘤学瘤学.
背景情况:
- T细胞耗尽 (Tex) 是在持续的抗原暴露下T细胞功能障碍的临界免疫状态.
- T细胞耗尽研究领域经历了显著的增长,科学出版物的激增证明了这一点.
- 图书统计分析提供了研究趋势,贡献和T细胞耗尽领域影响的定量概述.
研究的目的:
- 对2005年至2024年期间发表的T细胞耗尽 (Tex) 文献进行全面的文献分析.
- 确定T细胞耗尽领域的领先研究机构,国家和有影响力的作品.
- 绘制研究主题的演变图,并预测T细胞耗尽研究的未来热点.
主要方法:
- 从科学网络核心收藏 (2005-2024) 中获取了2831篇关于T细胞耗尽的出版物.
- 利用文献计量工具 (CiteSpace,VOSviewer) 进行共同作者,共同引用和共同发生的网络分析.
- 对研究成果,影响和关键词频率进行定量评估,以确定趋势和新兴领域.
主要成果:
- 关于T细胞枯竭的出版物显示呈指数级增长,美国和中国是主要贡献者.
- 化学抗原受体 (CAR) T细胞疗法,免疫疗法,免疫检查点抑制剂和瘤微环境是突出的研究领域.
- 未来的研究可能将集中在机器学习,泛癌研究,编程死亡-1封锁,scRNA-seq和免疫疗法耐药性.
结论:
- 这项研究提供了对T细胞耗尽文献 (2005-2024) 的第一个广泛的文献评估.
- 这些发现提供了关于T细胞耗尽研究当前情景和新兴趋势的宝贵见解.
- 这一分析为寻求了解该领域的关键发展和未来方向的研究人员提供了指南.
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