中枢甲状腺功能低下和心血管疾病:一项西班牙队列观察性研究
Fernando Guerrero-Pérez1,2, Pedro Iglesias3,4, Miguel Paja Fano5,6
1Department of Endocrinology and Nutrition, Hospital Universitari de Bellvitge, Barcelona, Spain. ferguepe@hotmail.com.
Hormones (Athens, Greece)
|August 18, 2025
概括
中部甲状腺功能低下症呈现出高患心血管风险因素的高患病率. 这些因素的发生率,心血管疾病和死亡率在这种疾病的单独和组合形式中都相似.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 中枢甲状腺功能低下症是一种罕见的内分泌疾病,有关心血管风险的数据有限.
- 了解心血管风险因素 (CVRF) 和心血管疾病 (CVD) 对于管理中枢甲状腺功能低下症患者至关重要.
研究的目的:
- 调查中枢甲状腺功能低下症成人中CVRFs,CVDs和死亡率的流行率和发病率.
- 为了比较患有孤立和联合中央甲状腺功能低下症的患者之间的心血管结果.
主要方法:
- 这是一项多中心,回顾性,观察性研究,涉及来自西班牙14家三级医院的637名中枢甲状腺功能低下症患者.
- 收集的数据包括基线人口统计数据,CVRFs,CVDs,以及在7.0年的中位数随访期间的结果.
主要成果:
- 在基线时,观察到高患病率的失脂血症 (34.2%),高血压 (31.4%),糖尿病 (13.2%) 的.
- 在随访期间,事件CVRF和CVD很常见,孤立和联合中央甲状腺功能低下症的发病率相似.
- 死亡率发生在7.2%的患者中,感染和心血管疾病是主要原因.
结论:
- 中枢甲状腺功能低下症与心血管风险因素的重大负担有关.
- 心血管疾病发病率和死亡率在孤立和联合中央甲状腺功能低下症之间没有显著差异.
- 需要进行进一步的研究,以阐明这种人群中心血管健康的具体管理策略.
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