不健康的生活方式加速了衰老和随之而来的肌肉骨疾病
Hao-Long Zhou1, Jiao-Jun Liang2, Jonathan K L Mak3
1Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Journal of bone and mineral metabolism
|August 18, 2025
概括
不健康的生活方式加速衰老,增加肌肉骨疾病的风险,如骨质疏松症和骨折. 衰老加速在这些关联中发挥着作用,突出了生活方式对骨健康的影响.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 关于不健康的生活方式对衰老和肌肉骨健康的综合影响的研究有限.
- 本研究利用英国生物库的数据来研究这些综合效应.
研究的目的:
- 分析综合不健康生活方式评分 (UHLS),衰老加速和肌肉骨疾病之间的关联.
- 探索衰老加速对与生活方式相关的肌肉骨问题的调解和联合影响.
- 使用孟德尔随机化研究潜在的因果关系.
主要方法:
- 从九种行为构建了一个不健康的生活方式得分 (UHLS).
- 从18个临床特征计算出衰老指标.
- 采用了通用线性和考克斯比例危险回归模型.
- 进行了门德尔随机化 (MR) 分析以进行因果推断.
主要成果:
- 较高的UHLS与加速衰老 (生物和表型年龄) 相相关,并增加了握力低,步行速度慢,骨质疏松症,骨折和骨关节炎的风险.
- 加速衰老部分介绍了不健康的生活方式和慢步,骨质疏松症和骨折等疾病之间的关系.
- 核磁共振分析表明,UHLS与握力低,骨关节炎和腿部部骨矿物质密度降低之间存在因果关系.
结论:
- 复合不健康的生活方式显著加速衰老过程.
- 加速衰老通过不健康的生活方式的调解和联合效应,促进肌肉骨疾病.
- 研究结果强调了改变生活方式对于维持肌肉骨健康和健康衰老的重要性.
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