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哺乳,青春期前肥胖,以及早期青春期的发展
Yunsoo Choe1,2, Soorack Ryu3,4, Jinjoo Choi5
1Department of Pediatrics, Hanyang University Guri Hospital, Guri, Republic of Korea.
JAMA network open
|August 18, 2025
概括
在前4-6个月的母乳养与儿童中部早期青春期 (CPP) 的风险降低有关. 这种保护作用部分是由于更低的青春期前脂肪,强调早期营养.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 公共卫生 营养 公共卫生 营养
- 童年发展 儿童发展
背景情况:
- 全球中部早期青春期 (CPP) 发病率正在上升,引发人们对长期健康影响的担忧.
- 早期养实践与CPP发展之间的关系尚不清楚.
研究的目的:
- 检查在前4-6个月的母乳养与儿童中CPP发病率之间的关联.
- 为了确定青春期前肥胖是否调解了这一关联.
主要方法:
- 一项全国性的回顾性队列研究,利用韩国国家医疗保险服务数据 (2007-2020年).
- 包括孩子在4-6个月和66-71个月的例行检查中.
- 通过护理人员问卷和使用ICD-10代码的CPP诊断以及GnRH激动剂治疗来分析养模式.
主要成果:
- 与纯母乳养相比,配方养与男孩 (AHR,1.16) 和女孩 (AHR,1.60) 的CPP风险增加有关.
- 混合养也显示男孩 (AHR,1.14) 和女孩 (AHR,1.45) 的CPP风险增加.
- 青春期前肥胖症占男孩的7.2%,女孩的17.8%.
结论:
- 婴儿早期的母乳养与较低的CPP风险有关.
- 这些发现强调了早期营养对于调节青春期时间的重要性.
- 部分母乳养的保护作用是通过预防儿童脂肪的介导.
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