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Updated: Sep 11, 2025

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非对称的FGF受体二元化:对FGF23生物学和药物发现的影响

Mohammed S Razzaque1, Moosa Mohammadi2

  • 1Department of Medical Education, School of Medicine, The University of Texas Rio Grande Valley, Edinburg, Texas, United States.

American journal of physiology. Cell physiology
|August 18, 2025
PubMed
概括

纤维细胞生长因子23 (FGF23) 需要αKlotho和肝酸硫酸蛋白糖 (HSPGs) 来激活FGF受体 (FGFRs) 进行矿物质和维生素D调节. 结构分析显示了一个不对称的FGF23-FGFR-αKlotho-HS组件驱动受体激活.

关键词:
在FGF受体.联邦政府财政基金23克洛托 (Klotho) 是一个古老的语言.酸盐酸盐的使用方法维生素D是维生素D的重要组成部分.

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