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半球间静止状态的功能连接与自发的神经相互作用相关.

Hyun Seok Moon1,2, Thanh Tan Vo1,2, Geun Ho Im1

  • 1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, Republic of Korea.

Proceedings of the National Academy of Sciences of the United States of America
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PubMed
概括

休息状态功能连接 (FC) 机制使用光遗传学在小鼠中进行了探索. 光遗传沉默揭示了多突触通路驱动自发的功能性大脑连接,与直接激活不同.

关键词:
有效的连接,有效的连接.功能性核磁共振成像 (MRI) 功能性核磁共振成像功能连接性的功能连接性视觉遗传学 视觉遗传学休息状态的休息状态.

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科学领域:

  • 神经科学是一个神经科学.
  • 系统神经科学 系统神经科学
  • 功能神经成像 功能神经成像

背景情况:

  • 功能性连接 (FC) 使用静止状态 (RS) 功能性MRI (fMRI) 绘制大脑网络,但缺乏对因果机制的理解,特别是对于强大的半球间连接.
  • 研究RS FC的神经基础对于理解大脑网络组织和功能至关重要.

研究的目的:

  • 研究小鼠休息状态功能连接 (FC) 的神经基础.
  • 区分自发性FC与唤起的神经活动的潜在因果机制.

主要方法:

  • 在小鼠中利用fMRI与在六个皮层区域内解剖学定义的模式光遗传激活和激发神经元的抑制相结合.
  • 采用光遗传沉默来抑制自发的神经活动,使fMRI能够在没有激发引起的干扰的情况下跟踪功能连接.
  • 基于结构连接 (SC) 的模拟突触路径长度依赖的连接.

主要成果:

  • 光遗传激活主要诱导皮层和皮下皮层的ipsilateral反应.
  • 光遗传沉默引发了更强烈的半球内和半球间皮质反应,反映了RS FC模式.
  • 自发的功能连接是通过多突触传播来解释的,而唤起的活动则依赖于单突触通路.

结论:

  • 多突触通路在塑造自发连接方面发挥着至关重要的作用.
  • 休息状态功能连接源于自发神经活动的因果相互作用,而不仅仅是直接的单突触连接.