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Updated: Sep 11, 2025

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通过合成和对接研究探索Pyrazole-Thiazole-Hydrazone化合物的SAR和抗真菌活性

Gresa Halimi Syla1,2, Derya Osmaniye1,2, Begüm Nurpelin Sağlık1,2

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.

Chemistry & biodiversity
|August 18, 2025
PubMed
概括

新的pyrazole-thiazole衍生物对Candida物种表现出强大的抗真菌活性,为现有治疗提供了有希望的替代方案. 这些化合物通过向14-α-胆固醇脱甲基酶来抑制厄戈斯特醇生物合成.

关键词:
14-α-胆固醇脱甲基酶的使用方法这是一种抗真菌药物.分子对接的分子对接.分子动力学分子动力学皮拉 (pyrazole) 是一种可怕的药物.提亚醇的使用方法

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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