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Updated: Sep 11, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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由EZH2抑制引起的表观遗传变化会增加具有高AID活性或DNA修复缺陷的B细胞的转位

Jianli Tao1, Luca Alessandri1, Alessandro Gasparetto1

  • 1Children Hospital Boston and Harvard Medical School, Boston, Massachusetts, United States.

Blood
|August 18, 2025
PubMed
概括

作为B细胞淋巴瘤的单一疗法,EZH2抑制剂是安全的,但将其与PI3Kδ抑制剂结合使用会增加染色体转位风险. 这是因为EZH2抑制增强了敏感细胞中的AID活性和基因组不稳定性.

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