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Updated: Sep 11, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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发现 ppGalNAc-T2 的小分子调节器,在循环关闭过程中准其转移稳定状态

Danfeng Shi1, Xialin Luo2, Lu Wang3

  • 1School of Chemical Engineering, Xuzhou College of Industrial Technology, Xuzhou 221140, China.

Bioorganic & medicinal chemistry letters
|August 18, 2025
PubMed
概括

研究人员确定了聚酸N-乙-银胺基转移酶2 (ppGalNAc-T2) 的新型小分子调节剂,这是代谢和神经发育障碍的关键标. 这项研究通过对多个蛋白质状态进行查,为药物发现提供了新的策略.

关键词:
药物发现 药物发现超稳定状态是指超稳定的状态.小分子调节器是小分子调节器.虚拟选是一个虚拟的选.ppGalNAc-T2 的时间.

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