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Updated: Sep 11, 2025

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
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A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s

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在加快储存条件下,晶体缺陷会导致拉尼蒂丁在拉尼蒂丁中形成尼托拉胺

Jianchao Xu1, Nicholas John Huls1, Amber S Jannasch2

  • 1Department of Industrial and Molecular Pharmaceutics, Purdue University, West Lafayette, IN 47907, USA.

Journal of pharmaceutical sciences
|August 18, 2025
PubMed
概括

在制造过程中引入的固态反应物种 (SSRS) 加快了ranitidine化物 (RAN) 中的尼托拉胺杂质的形成. 缓解SSRS对于制药产品的安全性和防止召回至关重要.

关键词:
低温磨粉是什么意思 低温磨粉是什么意思晶体缺陷是一个缺陷.在NDMA中,NDMA是最重要的.尼托胺是一种氨酸.物理稳定性 物理稳定性拉尼蒂丁胺化

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2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

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Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
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Nitrous acid and nitric acids are two types of acids containing nitrogen, among which nitrous acid is weaker than nitric acid. Nitrous acid with a pKa value of 3.37 ionizes in water to give a nitrite ion and the hydronium ion.
The nitrous acid is unstable. Hence, it is formed in situ from a solution of sodium nitrite and cold aqueous acids such as hydrochloric or sulfuric acid. In an acidic solution, the –OH group of nitrous acid undergoes protonation to give oxonium ion, followed by...
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Nitrous acid, a weak acid, is prepared in situ via the reaction of sodium nitrite with a strong acid under cold conditions. This nitrous acid prepared in situ reacts with primary arylamines to form arenediazonium salts. Such reactions are known as diazotization reactions. As shown in Figure 1, the formation of arenediazonium salts begins with the decomposition of nitrous acid in an acidic solution to give nitrosonium ions.
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Amines with low molecular weight are usually gaseous at room temperature, while those with high molecular weight are liquid or solids in nature. Usually, low molecular weight amines have a rotten fish-like smell. Diamines typically have a pungent smell. For instance, cadaverine and putrescine, depicted in Figure 1, are two molecules responsible for decaying tissue.
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