减少危害 刺激剂使用应急管理 减少和抗逆转录病毒疗法 在艾滋病毒初级保健中的坚持:实施有效性研究的协议
Gabriela Steiner1, Stefan Baral2, Elise D Riley1
1University of California, San Francisco, San Francisco, CA, United States.
JMIR research protocols
|August 18, 2025
概括
这项研究测试了HIV和兴奋剂使用障碍患者的新应急管理 (CM) 计划,鼓励减少兴奋剂使用和抗逆转录病毒治疗 (ART) 坚持. 该计划显示了可行性和可接受性在安全网诊所的承诺.
科学领域:
- 公共卫生 公共卫生
- 成 药物 药物 药物 药物
- 传染性疾病 传染性疾病
背景情况:
- 兴奋剂使用障碍 (SUD) 与艾滋病毒感染者的药物坚持不良和死亡率有关.
- 应急管理 (CM) 是推的SUD治疗方法,但面临实施挑战.
- 需要新的CM计划来解决贫困人口的双重SUD和HIV治疗需求.
研究的目的:
- 评估每周CM的可行性SUD和抗逆转录病毒疗法 (ART) 坚持在安全网艾滋病毒诊所.
- 评估这种新型CM干预措施在患者和医疗保健提供者中是否可接受.
主要方法:
- 在2个门诊艾滋病毒诊所进行试点,单臂,混合试验.
- 12周,每周一次的CM干预,激励负面兴奋剂测试和阳性tenofovir测试.
- 通过使用RE-AIM框架进行定量过程指标和定性访谈来评估可行性和可接受性.
主要成果:
- 招聘和CM访问将于2024年9月完成.
- 持续进行定量和定性数据分析,直到2025年10月.
- 初步的有效性将由尿液检测结果和HIV病毒抑制的变化来确定.
结论:
- 一个新的CM计划为减少兴奋剂使用和遵守ART提供了双重激励.
- 假设在安全网人群中,鼓励减少兴奋剂使用是可以接受的.
- 这种可行和可接受的模型可以支持更广泛地实施CM来减少刺激剂.
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