静脉血栓栓塞和动脉瘤之间的联系:流行病学,病理生理学和临床护理的影响
Antoine Bejjani1,2, Candrika D Khairani1,3, Darsiya Krishnathasan1
1Thrombosis Research Group, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
European heart journal. Acute cardiovascular care
|August 18, 2025
概括
静脉血栓塞栓症 (VTE) 和动脉血症,虽然历史上被分开看待,但具有共同的风险因素和机制. 本综述探讨了它们的相互联系和潜在的共享疗法.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 公共卫生 公共卫生
背景情况:
- 静脉血栓栓塞 (VTE),包括深静脉血栓塞 (DVT) 和肺栓塞 (PE),每年影响120万美国人.
- 动脉栓症包括心肌梗塞和中风,每年影响720,000名美国人.
- 从历史上看,VTE和动脉血症是不同的,它们具有共同的潜在病理生理特征和临床风险因素.
研究的目的:
- 批判性地评估链接VTE和动脉栓症的证据.
- 探索共享的病理生理机制和危险因素.
- 对这两种疾病的最新研究和治疗策略进行审查.
主要方法:
- 基础,翻译和临床研究的文献综述.
- 对VTE和动脉血栓发生率的流行病学数据的分析.
- 综合当前对共享疾病途径的理解.
主要成果:
- 证据表明,VTE和动脉血症的病理生理学和危险因素有显著的重叠.
- 共同点超越了"红色" (VTE) 和"白色" (动脉血症) 凝块的区别.
- 最近的研究强调了共享的分子和细胞机制.
结论:
- 静脉动脉瘤和动脉动脉瘤是密切相互关联的心血管疾病.
- 了解这些联系可以为开发新的,共享的治疗方法提供信息.
- 需要进一步的研究来充分阐明和利用这些共同点.
相关概念视频
Venous Thrombosis I: Introduction
40
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
40
Venous Thrombosis III: Interprofessional Care
22
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
34
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
34
Venous Thrombosis IV: Nursing Management
23
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
23
Anticoagulant Drugs: Low-Molecular-Weight Heparins
893
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
893
Pulmonary Embolism I: Introduction
45
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
45


