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Updated: Sep 11, 2025

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia
09:44

Flow Cytometric Analysis of Mitochondrial Reactive Oxygen Species in Murine Hematopoietic Stem and Progenitor Cells and MLL-AF9 Driven Leukemia

Published on: September 5, 2019

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向PRDX1通过破坏 redox 稳态破坏急性骨髓性白血病爆发和干细胞,从而损害了急性骨髓性白血病爆发和干细胞

Zhenghao Li1, Guangci Liu1, Ziren Chen2

  • 1Shenzhen University International Cancer Center, Shenzhen Key Laboratory of Precision Medicine for Hematological Malignancies, Guangdong Key Laboratory for Genome Stability and Human Disease Prevention, Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Marshall Laboratory of Biomedical Engineering, Institute for Inheritance-Based Innovation of Chinese Medicine, Base for International Science and Technology Cooperation: Carson Cancer Stem Cell Vaccines R&D Center, School of Basic Medical Sciences, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, PR China.

Cell death & disease
|August 18, 2025
PubMed
概括

一种新型化合物TH37在急性髓性白血病 (AML) 中准过氧化素1 (PRDX1). 用TH37抑制PRDX1显示出治疗AML和克服白血病干细胞 (LSCs) 中的治疗抵抗的前景.

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