高精度的透皮药物输送是通过双平行无门压电微实现的,该微与空心微针集成
Lei Zhang1,2, Wei Sha1,2, Yi Li3,4
1School of Microelectronics, Shanghai University, Shanghai, China.
Microsystems & nanoengineering
|August 18, 2025
概括
这项研究介绍了一种可穿戴的通过皮肤递送药物 (TDD) 装置,使用的是压电微. 非同步的双操作确保了精确,稳定的药物输送,在动物模型中证明了血糖控制有效的胰岛素输送.
科学领域:
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
- 微型技术 微型技术
背景情况:
- 通过皮肤输送药物 (TDD) 提供了符合患者需求的可穿戴解决方案.
- 无门的压电微提供了简单性和成本效益,但受到流动脉冲和反流的影响.
- 现有的TDD系统需要提高可控性和精度,以实现有效的治疗.
研究的目的:
- 开发一个可穿戴的TDD设备,集成一个双平行无门压电微和空心微针阵列.
- 为了提高精度,解决无门微中的流量脉冲和反流问题.
- 为了证明该设备能够控制药物输送和治疗效果.
主要方法:
- 使用3D打印技术制造TDD设备.
- 双平行无形压电微与空心微针阵列的集成.
- 利用双微的异步驱动来实现稳定的向前流量.
- 模拟分析和设备性能实验验证,包括流量和压力控制.
- 在体内动物研究以评估胰岛素输送和血糖调节.
主要成果:
- 具有异步驱动的双平行微有效消除了流动脉冲和反流.
- 实现了稳定的向前流量,具有出色的可控性和高精度.
- 证明可控制的输出流量 (大约. 1.61毫升/分钟) 和压力 (大约. 700 Pa) 通过驾驶信号.
- 在动物模型中通过TDD装置成功输送胰岛素,从而控制了血糖水平.
结论:
- 开发的可穿戴TDD设备为现有技术提供了低成本,高精度的替代方案.
- 异步双操作显著提高了无门压电微的稳定性和可控性.
- 该设备在可穿戴药物输送应用中显示出相当大的前景,特别是在慢性疾病管理方面.
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