发现了影响改善肌肉强度的肠道微生物
Ji-Seon Ahn1, Hae-Mi Kim2, Eui-Jeong Han1
1Gwangju Center, Korea Basic Science Institute, Gwangju, 61751, Republic of Korea.
Scientific reports
|August 18, 2025
概括
特定的肠道细菌可以增强肌肉力量,独立于宿主遗传. 补充老年小鼠的 Lactobacillus johnsonii 和 Limosilactobacillus reuteri 通过影响关键肌肉生长因素来增强肌肉力量.
科学领域:
- 微生物学 微生物学
- 肌肉生理学 肌肉生理学
- 肠道微生物组研究研究
背景情况:
- 人们越来越认识到肠道微生物对宿主生理学的影响.
- 对于像肌肉强度这样的复杂特征的特定微生物贡献仍然在很大程度上未被探索.
研究的目的:
- 为了识别与肌肉强度增强相关的特定肠道微生物菌株.
- 在体内调查已识别的细菌对肌肉强度的直接影响.
主要方法:
- 从人类移植便微生物群到小鼠.
- 肠道微生物组成与肌肉强度表型相关的分析.
- 用特定的细菌物种 (Lactobacillus johnsonii,Limosilactobacillus reuteri) 补充年龄大的小鼠.
- 测量肌肉组织mRNA表达的folistatin (FST) 和胰岛素样生长因子-1 (IGF1).
主要成果:
- 肠道细菌显著影响宿主肌肉的强度.
- 消化道中的不同微生物群落与不同的肌肉强度水平相关.
- 在老年小鼠中,Lactobacillus johnsonii和Limosilactobacillus reuteri补充剂增强了肌肉力量.
- 补充剂增加了肌肉组织中的FST和IGF1mRNA表达.
结论:
- 特定的肠道细菌,包括L. johnsonii和L. reuteri,可以直接提高肌肉力量.
- 肠道微生物组代表了一种用于增强肌肉功能的新型治疗点.
- 这项研究为了解微生物组在复杂生理特征中的作用奠定了基础.
关键词:
牛乳杆菌约翰尼尼 (Lactobacillus johnsonii) 是一个利莫西拉克托巴西勒斯 (Limosilactobacillus reuteri) 是一种植物.复杂的特征 复杂的特征便微生物群移植 便微生物群移植我们的肠道微生物组.肌肉的力量 肌肉的力量更多相关视频
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