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随机临床试验用于位定位与缓慢凝血循环光凝血在治疗黑色虹膜新血管玻璃眼的治疗中

Weerawat Kiddee¹, Kaneungnit Kittigoonpaisan², Sakhanit Leelaprasasne²

¹Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla province, 90110, Thailand. kweerawat@hotmail.com.

Scientific reports

|August 18, 2025

概括

与TSCPC相比,缓慢凝血透细胞循环光凝血 (SC-TSCPC) 对新血管玻璃眼 (NVG) 患者具有黑色虹膜提供了更好的眼内压力降低和安全性. 然而,SC-TSCPC需要更多的能量和会议.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
手术技巧手术技巧

背景情况:

神经血管光眼 (NVG) 在控制眼内压力 (IOP) 方面存在重大挑战.
穿细胞循环光凝血 (TSCPC) 是NVG的治疗选择,使用不同的能量传递技术.
在NVG患者的暗虹膜可能会影响TSCPC的疗效和安全性.

研究的目的:

为了比较TSCPC (PT-TSCPC) 与缓慢凝血TSCPC (SC-TSCPC) 的有效性和安全性,在治疗黑色虹膜的NVG患者中.
评估关键结果,包括IOP减少,成功率,视力敏度和并发症在五年后续.

主要方法:

一项随机临床试验,涉及97名亚洲NVG患者.
患者被分配到PT-TSCPC (1,500-2,500mW为2秒) 或SC-TSCPC (1,250mW为4秒).
评估的结果包括IOP,成功/反应率,再治疗率,疼痛 (NPRS),视力敏度 (VA) 和并发症.

主要成果:

与PT-TSCPC相比,SC-TSCPC实现了更大的IOP降低 (56%对45%),并且5年累计成功概率更高 (69.3%对48.6%).
PT-TSCPC需要的总能量显著减少 (78.3 J与99.7 J),但引起的眼睛疼痛更多 (NPRS 6与1.8).
SC-TSCPC需要更多的激光疗程 (22.4%对6.3%),并且与眼内炎症的风险更高有关 (HR 2.63).

结论:

缓慢凝血TSCPC显示了潜在的更有效的IOP降低和更好的NVG患者的安全概况与黑色虹膜.
弹出定位的TSCPC使用的能量更少,会议更少,但与眼睛疼痛增加有关.
在NVG中TSCPC失败的危险因素包括眼内炎症的恶化,PT技术和男性性别.

关键词:

循环摄影凝血是一种循环摄影凝血.黑色的虹彩是黑色的虹彩新血管性玻璃眼 (Neovascular Glaucoma) 是一种新血管性玻璃眼.流行标题的标题.缓慢凝固的凝血是一种缓慢凝固.

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