评估牙周炎和炎症性肠病之间的关联:系统性审查和元分析
Narges Naghsh1, Faezeh Karimi2, Moammad Javad Tarrahi3
1Dental Implants Research Center, Department of Periodontics, School of Dentistry, Isfahan University of Medical Sciences, Hezar Jrib Street, Isfahan, Iran.
BMC gastroenterology
|August 19, 2025
概括
炎症性肠病 (IBD) 与牙周炎的风险更高有关. 需要进一步的研究来证实这种关联,并探索IBD和牙疾病之间潜在的共同原因.
科学领域:
- 胃肠病学和牙周病学
- 系统性审查和元分析
背景情况:
- 牙周病与心脏病,糖尿病和怀孕等全身性疾病有关.
- 炎症性肠病 (IBD) 包括性结肠炎 (UC) 和克罗恩病 (CD).
研究的目的:
- 为了研究炎症性肠病 (IBD) 和牙周炎之间的关系.
- 评估IBD患者牙周炎的患病率,包括UC和CD亚组.
主要方法:
- 从1960年到2024年12月,对7个数据库 (PubMed,Scopus,Web of Science,ProQuest,Embase,Cochrane,ScienceDirect) 进行了系统的审查.
- 使用纽卡斯尔-太华检查清单进行的十一项纳入研究的质量评估.
- 在IBD患者中对牙周炎患病率的元分析与使用几率比率 (OR) 和综合元分析 (CMA) 软件的对照.
主要成果:
- 与对照组相比,IBD患者出现牙周炎的可能性明显更高 (OR:2.28;95%CI:1.73-3).
- 牙周炎的风险在UC (OR: 3.14;95%CI: 2.11-4.66) 和CD (OR: 1.99;95%CI: 1.4-2.83) 两组子组中都较高,尽管在统计学上并不显著 (P=0.09).
结论:
- 炎症性肠病与牙周炎的可能性增加有关.
- 需要进一步的纵向研究,采用更大的样本大小来验证这种关联,并阐明共同的潜在机制.
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