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血红氧酶-1多态性与缺血性心脏并发症和1型糖尿病全因死亡率有关
Heli Segersvärd1,2, Niina Sandholm3,4,5, Valma Harjutsalo2,6,7
1Minerva Foundation Institute for Medical Research, Biomedicum Helsinki 2, Helsinki, Finland.
血液氧化酶1 (HO-1) 基因变异,特别是GTn重复LL基因型和-413A/T AA基因型,与1型糖尿病 (T1D) 男人的缺血性心脏事件和死亡率增加有关. 这些关联在女性中没有观察到,这表明性别依赖的影响.
科学领域:
- 遗传学和心血管疾病
- 糖尿病研究研究 糖尿病研究
- 分子生物学和医学 分子生物学和医学
背景情况:
- 血液氧化酶1 (HO-1) 是一种具有心血管保护作用的诱导酶,由HMOX1基因编码.
- HMOX1基因中的多态,特别是GTn重复,影响其活性,并与心血管问题有关.
- 该研究调查了HMOX1基因变异,HO-1血清水平和1型糖尿病 (T1D) 的心血管结果之间的联系.
研究的目的:
- 检查HMOX1基因多态性和血清HO-1度与T1D患者的血管并发症和死亡率的相关性.
- 为了确定这些关联是否在两性之间存在差异.
主要方法:
- 来自芬兰糖尿病脏病研究 (FinnDiane) 的T1D个体中的HMOX1 GTn重复,-413A/T SNP (rs2071746) 和+99G/C SNP (rs2071747) 的基因定型.
- 测量血清HO-1度的方法.
- 基因型,血清HO-1水平和心血管事件或全因死亡率之间的关联分析,按性别分层.
主要成果:
- 在男性中,HMOX1 LL基因型 (GTn重复) 与缺血性心脏事件和全因死亡率的增加有关.
- -413A/T AA基因型也与男性更频繁的缺血性心脏事件有关.
- 对于这些多态性在女性中没有发现任何显著的关联;然而,女性中较高的HO-1血清水平与心血管疾病和药物需求相关. 男性的血清HO-1水平比女性高.
结论:
- HMOX1基因型变异,特别是LL GTn重复和AA-413A/T基因型,与T1D男性的缺血性心脏并发症和死亡率有关.
- 这些发现表明,HMOX1基因型在1型糖尿病患者心血管并发症的发展中起着性别相关的作用.
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