胃癌中与迁移体相关的预后基因:转录基因和免疫治疗分析
Wei Qiu1,2, Ke Zhang1,2, Wei Hu1,2
1Department of Laboratory Medicine, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian, Jiangsu, 223800, People's Republic of China.
OncoTargets and therapy
|August 19, 2025
概括
这项研究确定了八个与迁移体相关的基因作为胃癌 (GC) 的预后标志物. 开发的风险模型有助于个性化GC治疗策略和了解疾病的发病因子.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物信息学是一种生物信息学.
背景情况:
- 胃癌 (GC) 是癌症死亡的主要原因,具有复杂的致病性.
- 迁移体,新发现的有机体,影响瘤微环境和免疫反应,但它们在GC中的作用尚不清楚.
研究的目的:
- 确定在胃癌中具有预后价值的与迁移体相关的基因 (MRGs).
- 开发胃癌预后的预测模型,并探索治疗点.
主要方法:
- 来自TCGA和GEO数据库的综合转录组数据,包含35个MRG.
- 利用生物信息学分析,包括LASSO和Cox回归,用于预后模型的构建.
- 进行了GSEA,免疫透分析和药物敏感性评估,通过RT-qPCR验证了关键基因表达.
主要成果:
- 已经确定了八种预后性MRG:BMP1,CPQ,PDGFD,TSPAN5,TSPAN7,TGFB2,WNT11和LEFTY1.1等.
- 开发了一个具有预测性能的风险模型 (AUC>0.6) 并将其与TGF-β信号和免疫微环境特征联系起来.
- 在GC组织中验证了BMP1,LEFTY1,TGFB2的升调和TSPAN5的降调.
结论:
- 八个MRG在胃癌中具有预后意义.
- 已建立的风险模型为个性化GC治疗提供了新的分子标记物和潜在的治疗点.
- 这些发现为GC病原和创新的治疗策略提供了关键的见解.
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