Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Olfaction01:25

Olfaction

45.1K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
45.1K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.6K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Dietary habits and olfactory function in individuals with Parkinson's disease: an underexplored association.

Nutritional neuroscience·2026
Same author

Case report of Parkinson's disease in isolated congenital anosmia with absent olfactory bulbs.

NPJ Parkinson's disease·2026
Same author

[Preliminary validation of the Quebec French version of the Memory Binding Test: Comparison with the Rey Auditory Verbal Learning Test in adults aged 55 and older].

Geriatrie et psychologie neuropsychiatrie du vieillissement·2026
Same author

Polypharmacology is an enduring and nearly universal property of kinase inhibitors.

bioRxiv : the preprint server for biology·2026
Same author

TYK2 mediates neuroinflammation in Alzheimer's disease brains with TDP-43 pathology.

Nature communications·2026
Same author

Human olfactory sensitivity varies across geographical locations.

Scientific reports·2026

相关实验视频

Updated: Sep 11, 2025

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.2K

主观认知衰退下较低的气味识别:一个元分析.

Benoît Jobin1,2,3, Zigrand Coline4,5, Johannes Frasnelli2,6,5

  • 1Department of Psychology Université du Québec à Trois-Rivières Trois-Rivières Québec Canada.

Alzheimer's & dementia (Amsterdam, Netherlands)
|August 19, 2025
PubMed
概括

报告主观认知衰退 (SCD) 的人与认知正常的人相比,嗅觉识别较差. 这种嗅觉缺陷可能会在一般认知能力下降之前发生,这表明它有可能成为早期阿尔茨海默病的生物标志物.

关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.生物标志物生物标志物这是一个元分析.嗅觉 嗅觉是一种嗅觉.嗅觉识别 嗅觉识别是一种识别方式.味道 味道 味道 味道 味道主观认知衰退 主观认知衰退

更多相关视频

A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.7K
Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

22.2K

相关实验视频

Last Updated: Sep 11, 2025

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.2K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.7K
Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

22.2K

科学领域:

  • 神经科学是一个神经科学.
  • 老年学是一门学科.
  • 生物标志物发现发现

背景情况:

  • 嗅觉识别的下降与阿尔茨海默病 (AD) 生物标志物有关.
  • 嗅觉缺陷可能出现在认知障碍之前,在主观认知衰退 (SCD) 阶段.

研究的目的:

  • 为了比较SCD和认知正常 (CN) 个体之间的气味识别能力.
  • 研究嗅觉功能作为临床前AD的潜在早期指标.

主要方法:

  • 在四个数据库中进行系统的文献搜索,寻找50岁以上成年人嗅觉识别和认知查研究.
  • 11项研究的随机效应元分析,包括660名SCD参与者和574名CN参与者.

主要成果:

  • 患有SCD的个体的气味识别得分明显低于CN参与者 (SMD = -0.67,p=0.04).
  • 超回归表明认知和嗅觉差异 (β = -1.79,p = 0.02) 之间存在负相关性,尽管认知差异最小,但SCD的嗅觉下降.

结论:

  • 在SCD患者中观察到较低的气味识别,这表明嗅觉下降在一般认知下降之前.
  • 嗅觉识别显示为预临床阿尔茨海默病中神经退行症早期查工具的前景.
  • 研究强调,由于观察到的异质性,需要采用多模式生物标志物方法.