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主观认知衰退下较低的气味识别:一个元分析
Benoît Jobin1,2,3, Zigrand Coline4,5, Johannes Frasnelli2,6,5
1Department of Psychology Université du Québec à Trois-Rivières Trois-Rivières Québec Canada.
Alzheimer's & dementia (Amsterdam, Netherlands)
|August 19, 2025
概括
报告主观认知衰退 (SCD) 的人与认知正常的人相比,嗅觉识别较差. 这种嗅觉缺陷可能会在一般认知能力下降之前发生,这表明它有可能成为早期阿尔茨海默病的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物发现发现
背景情况:
- 嗅觉识别的下降与阿尔茨海默病 (AD) 生物标志物有关.
- 嗅觉缺陷可能出现在认知障碍之前,在主观认知衰退 (SCD) 阶段.
研究的目的:
- 为了比较SCD和认知正常 (CN) 个体之间的气味识别能力.
- 研究嗅觉功能作为临床前AD的潜在早期指标.
主要方法:
- 在四个数据库中进行系统的文献搜索,寻找50岁以上成年人嗅觉识别和认知查研究.
- 11项研究的随机效应元分析,包括660名SCD参与者和574名CN参与者.
主要成果:
- 患有SCD的个体的气味识别得分明显低于CN参与者 (SMD = -0.67,p=0.04).
- 超回归表明认知和嗅觉差异 (β = -1.79,p = 0.02) 之间存在负相关性,尽管认知差异最小,但SCD的嗅觉下降.
结论:
- 在SCD患者中观察到较低的气味识别,这表明嗅觉下降在一般认知下降之前.
- 嗅觉识别显示为预临床阿尔茨海默病中神经退行症早期查工具的前景.
- 研究强调,由于观察到的异质性,需要采用多模式生物标志物方法.
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