没有可识别的病原体的复发性无菌性脑膜炎:一个病例报告
Saima Nazish1, Abdulhadi J Alotaibi2, Obaid M Aljarbou1
1Neurology, Imam Abdulrahman Bin Faisal University, Dammam, SAU.
Cureus
|August 19, 2025
概括
没有明确原因的复发性脑膜炎构成了诊断挑战. 这一案例突显了异常无菌性脑膜炎作为一种考虑因素,当排除感染时,强调多学科护理.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 内部医学 内部医学
背景情况:
- 没有可识别的病原体的复发性脑膜炎 presents一个重要的诊断挑战,特别是与同时存在的系统性并发症.
- 一名66岁的男性患有多种并发病,在6年内经历了5次脑膜炎发作.
研究的目的:
- 讨论复发性脑膜炎的一个具有挑战性的病例,广泛的调查未能确定传染性或全身病因.
- 强调在未被诊断的复发性脑膜炎病例中考虑异常无菌性脑膜炎的重要性.
主要方法:
- 一个患有复发性脑膜炎的患者的详细临床病例介绍.
- 综合诊断工作包括脑脊液 (CSF) 分析,序列聚合酶连锁反应 (PCR) 面板,微生物培养,自身免疫和瘤查以及脑磁共振成像 (MRI).
主要成果:
- 该患者出现了脑膜炎的反复发作,其特点是头痛,部硬,吐和神经缺陷.
- 脑液分析始终显示淋巴细胞多细胞化和高蛋白质与无菌培养.
- 广泛的微生物学,自身免疫和神经瘤的调查是负面的.
- 大脑MRI显示了无膜病变的脑膜增强,没有膜病变.
结论:
- 当针对传染性或全身性脑膜炎复发原因的详尽调查结果呈阴性结果时,应考虑异常无菌性脑膜炎.
- 最佳的管理涉及结构化诊断方法,多学科团队参与,避免不必要的抗菌药物.
- 分享此类病例可以提高临床意识和对异常性脑膜炎复发机制的理解.
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