在心力衰竭中,表皮,内脏和皮下脂肪组织与保存的喷射分数
Michelle Lobeek1, Lea P A Timmann1, Dirk J van Veldhuisen1
1Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
ESC heart failure
|August 19, 2025
概括
在心力衰竭中,男性比女性有更多的内脏脂肪组织 (VAT) 和心表脂肪组织 (EAT). 脂肪组织分布的这种差异可能会影响HFpEF患者的心血管风险.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 医疗成像医学成像
背景情况:
- 肥胖症在心力衰竭中普遍存在,具有保存的喷射分数 (HFpEF),脂肪组织 (AT) 显著影响其病理生理学.
- 了解不同AT仓库的分布对于管理HFpEF至关重要.
研究的目的:
- 研究HFpEF患者内脏AT (VAT),皮下AT (SAT) 和心上AT (EAT) 的分布和相互关系.
- 探索该患者群体内AT储存分布的潜在性别特异性差异.
主要方法:
- 预期招募HFpEF患者 (左心室喷射分数>40%).
- 利用多模式成像,包括心磁共振 (CMR) 进行EAT和全身计算机断层扫描 (CT) 进行VAT和SAT.
- 采用线性回归分析来确定EAT与其他AT存储之间的关联,并对共变量进行调整.
主要成果:
- 分析了68名患者 (平均年龄为73岁,50%为女性). 观察到肥胖率高 (38%),腰围增加 (91%) 和增值税增加 (85%).
- 与女性相比,男性的EAT和VAT数量明显高,而女性的SAT数量更高.
- 调整后的分析显示,增值税和EAT之间存在显著的关联 (R2=0.40),但增值税和SAT之间没有.
结论:
- 在HFpEF患者中AT存储的分布中存在显著的性别差异,男性积累更多的VAT和EAT.
- 脂肪组织分布的这些变化可能导致在HFpEF队列中观察到的与性别有关的心血管风险差异.
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