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HIF-1减弱了高纤维饮食中介的结肠表皮的增殖和干性

Pollyana Ribeiro Castro¹, Renan Oliveira Corrêa^1,2, Monara Kaélle Sérvulo Cruz Angelim³

¹Laboratory of Immunoinflammation, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, SP, Brazil.

|August 19, 2025

概括

像胰岛素这样的食纤维促进肠道缺氧,并稳定肠道细胞中的缺氧诱导因子1 (HIF-1). 这一过程依赖于肠道微生物,影响干细胞功能和结肠上皮代谢.

科学领域:

微生物学和宿主免疫相互作用
胃肠道生理学胃肠道生理学
营养科学营养科学

背景情况:

食纤维显著影响肠道微生物群和宿主生理学.
溶解纤维的胰岛素诱导由微生物产品介导的结肠上皮细胞变化.
了解饮食-微生物群-宿主相互作用对于肠道健康至关重要.

研究的目的:

调查胰岛素对肠道缺氧和肠道上皮细胞 (IEC) 中HIF-1信号传递的影响.
探索微生物群和宿主因子在调解这些影响中的作用.
阐明HIF-1稳定如何影响肠干细胞 (ISC) 功能和新陈代谢.

主要方法:

采用了多种omics方法,结合了饮食干预和肠道器官.
利用遗传和药理干预来研究缺氧诱导因子1 (HIF-1) 信号传递.
评估了对肠道上皮细胞 (IEC) 的微生物群和宿主依赖的影响.

主要成果:

摄入胰岛素可以促进肠道缺氧,并稳定IEC中的HIF-1.
这种稳定性取决于宿主和肠道微生物群.
HIF-1稳定通过微生物群依赖的代谢重编程来调节ISC功能.

结论:

胰岛素是一种可溶性纤维,在调节肠道缺氧和HIF-1信号传递方面发挥着重要作用.
HIF-1 作为微生物群依赖的表皮代谢和结肠中的增殖的关键调解者.
这些发现强调了HIF-1在复杂的饮食-微生物群-宿主轴中未被认可的作用.

关键词:

氧气过低是因为缺氧.食纤维是一种食物纤维.肠道干细胞是指肠道干细胞.在这种情况下,胰岛素和胰岛素是不同的,而胰岛素和胰岛素是不同的.代谢过程中的代谢.我们的微生物群.

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