牙周炎治疗和动脉内膜介质厚度的进展:一项随机试验
Marco Orlandi1,2, Stefano Masi3,4, Ersilia Lucenteforte5
1Periodontology Unit, UCL Eastman Dental Institute, Rockefeller Building, 21 University Street, London WC1E 6DE, UK.
European heart journal
|August 19, 2025
概括
在患有牙周炎 (PD) 的患者中,密集性牙周治疗 (IPT) 显著降低了 carotid intima-media 厚度 (cIMT) 和改善了内皮功能. 这突显了治疗牙疾病对心血管的益处.
科学领域:
- 心血管健康 心血管健康
- 牙周病学 牙周病学
- 血管生物学 血管生物学
背景情况:
- 牙周炎 (PD) 与内皮功能障碍有关.
- 密集性牙周治疗 (IPT) 对血管结构变化的影响尚不清楚.
- 这项研究研究了IPT对动脉内膜介质厚度 (cIMT) 的影响.
研究的目的:
- 为了评估IPT对cIMT在2年的影响.
- 评估二次结果,包括流媒体扩张 (FMD),血压和脉冲波速度 (PWV).
- 探索解释性结果,如炎症,氧化应激和代谢学.
主要方法:
- 一项为期2年的随机临床试验,涉及135名患有PD的参与者.
- 参与者被随机分配到IPT (n=68) 或控制牙周治疗 (CPT,n=67).
- cIMT,口,血压,PWV和生物标志物被测量在不同的时间间隔.
主要成果:
- 在24个月后,IPT显著降低了cIMT与CPT相比 (P < 0.0001).
- 在IPT组中,口病在2个月内显著改善,并在整个研究期间保持较高 (P < 0.0001).
- 在IPT组中,糖蛋白乙水平下降,表明炎症/氧化应激减少.
结论:
- 密集的牙周治疗促进了有利的结构性血管变化.
- 牙周炎显著影响心血管健康.
- 治疗牙周炎可能会改善心血管结果.
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