危及生命的喘发作和儿童喘相关死亡的危险因素-系统性审查
Aleksandra Gawlik-Lipinski1, Sarah Hassen1, Manisha Ramphul1,2
1University of Leicester, Leicester, UK.
Pediatric pulmonology
|August 19, 2025
概括
确定儿童和青少年严重喘发作 (CYP) 的危险因素至关重要. 高胺醇使用,先前住院和社会经济地位与喘性CYP的重症监护病房入院有关.
科学领域:
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
- 喘研究 喘研究
背景情况:
- 喘死亡率和危及生命的喘发作对儿童和青少年 (CYP) 构成重大风险.
- 关于CYP中严重喘恶化特定风险因素的证据有限.
- 本系统性审查旨在巩固有关这些风险因素的当前知识.
研究的目的:
- 系统地审查和综合观察性研究,确定危及生命的喘发作和儿童和年轻人的喘死亡率 (CYP) 的风险因素.
- 为儿童喘护理中的风险预测策略提供信息.
主要方法:
- 按照PRISMA指南进行系统审查,在PROSPERO.上注册.
- 包括从2000年起以英语出版的观察性研究 (0-18岁),重点关注喘死亡率和重症监护室 (ICU) 住院.
- 搜索了CINAHL,MEDLINE,Cochrane图书馆和Scopus;通过叙述方式合成了结果.
主要成果:
- 包括来自高收入国家的六项研究 (五项追溯队列,一项病例控制).
- 与重症监护室入院相关的因素包括高沙布他的使用,先前住院,低社会经济地位,过敏,黑人种族,喘药物处方,肺炎病史,农村地区,青春期,父亲喘和并发症.
- 与白人儿童相比,黑人种族与喘死亡率增加7倍的风险有关.
结论:
- 少数异质性研究强调需要更强大的流行病学研究.
- 改进的风险预测模型对于在CYP中管理近乎致命和致命的喘发作至关重要.
- 目前的证据表明,在儿童群体中影响严重喘结果的显著差异和危险因素.
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