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Updated: Sep 11, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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点占用-杆扰动策略使得迅速发现强大的CDK2-环素A2相互作用抑制剂成为可能

Ge Sun1,2, Shuaishuai Chi1,3, Jiacheng Li1,2

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P.R. China.

Angewandte Chemie (International ed. in English)
|August 19, 2025
PubMed
概括

一个新的"Fulcrum Occupancy-Leverage Perturbation (FOLP) "战略迅速设计出强大的蛋白质与蛋白质相互作用 (PPI) 抑制剂. 这种方法导致发现了一种新的CDK2-Cyclin A2抑制剂LC-K2CAin-3,显示出显著的治疗潜力.

关键词:
CDK2 - 环素 A2 的基因.抑制剂设计策略的设计策略黑色素瘤是一种黑色素瘤.蛋白质蛋白质相互作用

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