紧急呼吁欧盟委员会简化和将IVDR第5.5条置于特定和精确诊断的背景下
Christa Cobbaert1, Christian Schweiger2, Christoph Buchta3
1Department of Clinical Chemistry and Laboratory Medicine, 4501 Leiden University Medical Center , Leiden, The Netherlands.
Clinical chemistry and laboratory medicine
|August 19, 2025
概括
欧盟体外诊断法规 (IVDR) 面临着挑战. 建议修改第5.5条,以简化内部IVD (IH-IVD),确保患者安全和获得罕见疾病测试.
科学领域:
- 监管科学 监管科学
- 临床诊断 临床诊断 临床诊断
- 医疗保健政策 医疗保健政策
背景情况:
- 欧盟委员会 (EC) 正在评估欧盟IVDR 2017/746的有效性和实施挑战.
- 正在收集利益相关者的反,以在2025年底之前为潜在的监管修订提供信息.
- 内部IVD (IH-IVD) 在欧盟医疗保健系统中发挥着至关重要的作用.
研究的目的:
- 建议对IVDR第5.5条进行系统性修改.
- 为解决IVD制造商和医疗实验室的实施挑战和意外后果.
- 确保患者安全和临床实用性,同时支持专业和孤儿试验.
主要方法:
- 对欧盟IVDR的利益相关者反的分析 2017/746.
- 对内部IVD (IH-IVD) 的现行监管要求的审查.
- 制定修订IVDR第5.5条的建议.
主要成果:
- IVDR的第5.5条规定了可能阻碍基本IH-IVDs可用性的条件.
- 目前的质量管理基础设施 (ISO 15189:2022) 和实验室专家的专业性已经得到监测.
- 通过从第5.5条中删除不必要的要求,可以防止过度监管.
结论:
- 应该修改IVDR的第5.5条,删除条件 (a) 和 (d) 到 (i),保留条件 (b) 和 (c).
- 修订第5.5条将通过利用现有的质量管理系统,防止对患者和护理人员的服务缺失.
- 修改IVDR确保了对罕见病患者的关键专业和孤儿测试的可持续性.
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