在9/11后的退伍军人中,创伤性脑损伤和加速表观遗传衰老
Kyle J Bourassa1, Sarah L Martindale, Melanie E Garrett
1Author Affiliations: VISN 6 Mid-Atlantic Mental Illness, Research Education and Clinical Center (MIRECC), Durham, North Carolina (Dr Bourassa, Dr Martindale, MIRECC Workgroup, Dr Beckham, Dr Kimbrel, and Dr Rowland); Durham VA Health Care System, Durham, North Carolina (Dr Bourassa); Department of Psychology, Georgetown University, Washington, District of Columbia (Dr Bourassa); Salisbury VA Health Care System, Salisbury, North Carolina (Dr Martindale and Dr Rowland); Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, North Carolina (Dr Martindale and Dr Rowland); Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina (Ms Garrett and Dr Ashley-Koch); Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina (Dr Beckham and Dr Kimbrel); and Health Services Research and Development ADAPT Center of Innovation, Durham, North Carolina (Dr Kimbrel).
退伍军人的创伤性脑损伤 (TBI) 与更快的生物衰老有关. 这种加快的衰老可能解释了这一群体的健康状况不佳和死亡风险增加.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 遗传学 是一个遗传学.
背景情况:
- 服兵役与增加受伤风险有关,包括创伤性脑损伤 (TBI).
- 经历TBI的退伍军人往往会经历不良健康结果和更高的死亡率.
- 加速生物衰老是将TBI与负面健康后果联系起来的潜在机制.
研究的目的:
- 调查TBI与9/11后退伍军人的表观遗传衰老率之间的关联.
- 为了确定加速的生物衰老是否有助于TBI退伍军人的健康状况不佳.
主要方法:
- 利用了来自VA中大西洋MIRECC部署后心理健康队伍的1152名9/11后退伍军人的数据.
- 在临床面试中通过自我报告评估TBI史,分类为没有,1或2+TBI组.
- 使用DunedinPACE测量了表观遗传衰老,来自DNA甲基化数据.
主要成果:
- 更多终身TBI或部署相关TBI的退伍军人表现出更快的表观遗传衰老.
- 在服务期间或之后发生的TBI与加速衰老的关联比服务前的TBI更强.
- 与部署相关的TBI对女性退伍军人加速衰老的影响更为明显.
结论:
- 创伤与退伍军人加速衰老的风险增加有关.
- 识别与TBI相关的加速衰老可以帮助确定与年龄相关的健康问题有风险的退伍军人.
- 早期发现加速衰老可能会引导干预措施,以减轻退伍军人过渡的长期健康风险.
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