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Updated: Sep 10, 2025

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有效释放COS/H₂S 通过基于BODIPY的光化基基基基酸盐

Yanmei Li¹, Emily Kryvorutsky¹, Yuanwei Zhang¹

¹Department of Chemistry and Environmental Science, New Jersey Institute of Technology, Newark, New Jersey 07103, USA. yuanwei.zhang@njit.edu.

Journal of materials chemistry. B

|August 19, 2025

概括

研究人员开发了基于BODIPY的新型thionocarbamates,在光激活时迅速释放硫化 (H₂S). 这一突破为生理条件和治疗应用中H2S输送提供了精确的控制.

科学领域:

化学生物学化学生物学
摄影化学的使用.
药用化学医学化学

背景情况:

控制生产和输送硫化 (H2S),一个重要的气体传递物,存在重大挑战.
对H₂S研究和治疗应用而言,响应性化学工具的开发至关重要.

研究的目的:

开发新的可光激活的化学工具,用于控制的H2S生成和输送.
在生理条件下研究这些新工具的疗效和动力学.

主要方法:

使用二甲 (BODIPY) 支架合成甲酸衍生物.
光激活研究以诱导碳硫化物 (COS) 释放和随后的H2S生成.
活细胞成像验证快速的H2S释放动力学.
密度函数理论 (DFT) 计算以阐明光解机制.

主要成果:

开发了基于BODIPY的thionocarbamates,在光激活后迅速释放COS,使H₂S产生.
实现了异常快速的脱速度,比相应的碳酸盐快100倍以上.
在活细胞成像研究中证明了精确和快速的H2S释放控制.
DFT的计算将增强的光解归因于thiocarbonyls的热力学不稳定性.

结论:

基于氨酸的BODIPY衍生物代表了快速H₂S释放的光设计的重大进步.
这些化合物为生物系统中精确的H2S输送提供了多功能平台.
这些发现为H2S相关的治疗策略和基础研究开辟了新的途径.

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