与术后非类固醇抗炎药物相关的术后出血风险:叙述性综述
Laura L Seitz1, Sanny Juresic2, Leslie R Siegel3
1Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, USA.
Journal of pain & palliative care pharmacotherapy
|August 19, 2025
概括
术后非类固醇抗炎药物 (NSAIDs) 对术后出血风险的影响很小. 选择性NSAIDs可能为手术后的疼痛管理提供更安全的替代方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 手术医学 手术医学
- 基于证据的实践.
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 通常用于治疗疼痛和炎症.
- 人们对NSAID相关的出血风险存在担忧,特别是在外科手术过程中.
- 在外科手术期间使用NSAID的安全性仍然是争论的主题.
研究的目的:
- 审查最近的文献 (过去10年) 关于与外科期间NSAID使用相关的术后出血风险.
- 综合有关NSAIDs对手术后出血并发症的影响的证据.
主要方法:
- 对随机对照试验,元分析和评论进行系统的文献搜索.
- 包括研究成年患者手术后出血事件的研究.
- 选和审查11篇选定的文章.
主要成果:
- 经过审查的文献表明,外科手术期间的NSAIDs通常对术后出血的影响很小.
- 研究检查了手术后出血的发生率,失血,血红蛋白的下降,以及血瘤/出血的频率.
- 与非选择性NSAID相比,选择性NSAID可能具有较低的出血风险.
结论:
- 在外科手术期间使用NSAID似乎对术后出血风险的影响很小.
- 在外科手术中,选择性COX-2药物可能比非选择性NSAID更可取.
- 个性化的患者和程序因素应指导在外科手术期间NSAID决策.
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