氧化应激调解了美国成年人的制阻燃剂和高脂血症之间的关联
Xiaodong Li1, Juan Liao2,3, Zhenhua Chen4
1Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.
International journal of environmental health research
|August 19, 2025
概括
制阻燃剂 (BFRs) 与高脂血症有关,这是一种高胆固醇和甘油三的情况. 由GGT表示的氧化应激调解了这种关系,突出了BFRs作为代谢疾病的危险因素.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 代谢性疾病研究研究
背景情况:
- 制阻燃剂 (BFR) 是与代谢疾病相关的持久性有机污染物 (POP).
- BFRs与高脂血症之间的特定关联以及氧化应激的作用需要进一步研究.
研究的目的:
- 检查暴露于单个和混合BFR和高脂血症之间的关系.
- 调查氧化应激在BFRs-超脂血症关联中的中介作用.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2005-2016) 中对6800名参与者的横截面分析.
- 使用加权多重物流回归,加权量子和 (WQS) 回归和量子g计算 (QGcomp) 模型.
- 评估了BFRs,脂质样本 (TC,TG,LDL-C) 和氧化应激标志物γ-glutamyltransferase (GGT) 之间的关联.
主要成果:
- 在特定的BFR (PBB153,PBDE28) 和高脂血症之间发现了显著的关联.
- 混合BFR暴露显示出与高脂血症的积极关联.
- BFR与增加的总胆固醇,甘油三和LDL-C有关.
- 氧化应激标志物GGT调解了BFR和高脂血,TC和TG之间的关系.
结论:
- BFR与高脂血症和不良脂质样本的患病率增加有关.
- 氧化应激在BFRs对脂质代谢的有害影响中起着重要的调解作用.
- 结果表明BFRs是代谢功能障碍的潜在环境风险因素.
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