癌症治疗后口腔微生物组的改变:一个范围审查和分析
Francis A Boksa1, Leah I Leinbach1,2, Drashty P Mody1,3
1Oral Immunobiology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg 30, Rm 303; MSC 4340, 30 Convent Drive, Bethesda, MD, 20892, USA.
Medical oncology (Northwood, London, England)
|August 19, 2025
概括
化疗和辐射等癌症疗法显著改变了口腔微生物组,增加了有害细菌. 了解这些转变对于癌症幸存者的口腔健康管理至关重要.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 口腔健康 口腔健康
背景情况:
- 癌症疗法对口腔有着深刻的影响.
- 癌症治疗后的口腔微生物组变化尚未完全理解.
- 放射和化疗等疗法可以导致口腔失生症.
研究的目的:
- 综合有关癌症治疗期间口腔微生物组变化的现有文献.
- 将发现分类并确定研究缺口.
- 为未来有关癌症幸存者的口腔健康研究提供信息.
主要方法:
- 对癌症患者口腔微生物组的62项研究进行了范围审查.
- 分析涉及化疗,放射治疗和干细胞移植的研究.
- 评估微生物多样性和特定种群的变化.
主要成果:
- 化疗,放射和干细胞移植导致了实质性的口腔微生物社区变化.
- 增加物种丰富性但减少口腔微生物群的均性是常见的.
- 观察到有益细菌的减少 (例如,链球菌) 和病原体的增加 (例如,Candida albicans).
结论:
- 癌症疗法诱导显著的口腔微生物组变化.
- 特定的治疗方式对口腔微生物组成有不同的影响.
- 需要进一步的研究来了解癌症幸存者的长期口腔健康影响.
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