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在成年人,青少年和儿童中使用离散选择实验引发和定健康状态偏好
Shitong Xie1,2, Tianxin Pan3, Juan Manuel Ramos-Goni4,5
1School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
PharmacoEconomics
|August 19, 2025
概括
加拿大的儿童,青少年和成年人对健康状况的偏好有所不同. 离散选择实验 (DCE) 显示了青少年使用定任务的可行性,持续时间任务的表现优于死亡任务.
科学领域:
- 卫生经济学 卫生经济学
- 心理测量 心理测量 心理测量
- 患者报告的结果
背景情况:
- 了解健康状态偏好对于卫生政策和资源分配至关重要.
- EQ-5D-Y-5L是衡量年轻人群体健康状况的宝贵工具,但偏好诱导需要谨慎的方法.
- 离散选择实验 (DCE) 越来越多地用于评估健康状况,但它们在不同年龄组中的应用需要验证.
研究的目的:
- 在加拿大使用DCE的儿童,青少年和成年人中比较EQ-5D-Y-5L仪器对健康状况的偏好.
- 评估使用重新缩放潜伏DCE与青少年定任务的可行性.
- 为了比较DCE与持续时间的性能与DCE与死任务的性能.
主要方法:
- 一项在线调查从546名儿童 (12-15岁),508名青少年 (16-17岁) 和908名成年人 (≥18岁) 中收集了使用隐性DCE任务的偏好.
- 成人和青少年完成了额外的定任务 (持续或死亡的DCE),以促进重新缩放.
- 混合逻辑模型分析了潜伏的DCE数据;在成人和青少年之间估计和比较定DCE模型.
主要成果:
- 儿童发现DCE任务比青少年和成年人更容易完成.
- 在成年人的潜伏DCE模型中观察到系数的单调性,但在儿童或青少年中没有.
- 固定DCE建模在成年人中表现更好,而不是青少年;持久DCE的结果略好于持久DCE的结果.
结论:
- 儿童/青少年和成年人之间的EQ-5D-Y-5L健康状况偏好存在显著差异,以DCEs来衡量.
- 使用DCE的定任务对青少年来说是可行的,基于持续时间的方法显示出略高的性能.
- 这些发现为DCE的应用提供了信息,用于评估加拿大的不同年龄组的健康状况.
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