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儿童癌症幸存者的下尿路功能障碍 - 在三级护理医院的前性研究
Swathi Pm1, Vasudeva Bhat K1, Surag Kr2
1Department of Pediatric Oncology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576104.
International urology and nephrology
|August 19, 2025
概括
下尿道功能障碍 (LUTD) 影响超过20%的儿童癌症幸存者. 盆腔辐射和某些化疗剂是显著的风险因素,需要进行例行查.
科学领域:
- 儿科瘤学 儿科瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 幸存者护理 幸存者护理
背景情况:
- 下尿道功能障碍 (LUTD) 是儿童癌症幸存者的未被认可的晚期影响.
- 潜在的促成因素包括神经毒性化疗,盆腔瘤和辐射暴露.
研究的目的:
- 确定儿童癌症幸存者的LUTD的患病率和严重程度.
- 在这个人群中识别与LUTD相关的风险因素.
主要方法:
- 对92名儿童癌症幸存者 (年龄≥5岁) 的前性观察研究.
- 使用下尿道功能障碍评分系统 (DVSS) 进行查;诊断标准:DVSS ≥9 (男性) 或≥6 (女性).
- 临床和治疗变量的分析;对DVSS阳性病例的尿液流量计和超声学.
主要成果:
- 在21.7%的幸存者 (20/92) 中发现了LUTD,女性 (31.6%) 与男性 (14.8%) 的患病率更高.
- 发现与盆腔瘤,盆腔辐射,Vinca类化合物使用和高剂量的化剂有显著的关联.
- 异常排泄模式在95%的DVSS阳性患者中得到证实;保守的管理是最常见的.
结论:
- 在儿童癌症幸存者中,LUTD很普遍,特别是那些接受Vinca类化合物和盆腔导向疗法的儿童癌症幸存者.
- 常规的DVSS查应纳入早期检测和干预的长期随访协议.
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