培养证明多菌性胃肠道感染在儿童中很罕见
Richard Kellermayer1,2, Savini L Britto1, Rohan N Britto3
1From the Division of Pediatric Gastroenterology, Texas Children's Hospital; Baylor College of Medicine, Houston, Texas.
The Pediatric infectious disease journal
|August 19, 2025
概括
儿童便培养显示,随着年龄的增长,阳性率下降. 与先前使用抗生素相关的多阳性结果,仅在幼儿中观察到,强调肠道防御成熟和抗生素管理.
科学领域:
- 儿童传染病 儿童传染病
- 微生物学 微生物学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 胃肠道感染在儿童中很常见.
- 肠道微生物群和免疫系统成熟影响感染易感性.
- 抗生素的使用可以破坏肠道微生物群.
研究的目的:
- 根据年龄来确定儿科便培养的阳性率.
- 调查多阳性便培养的发生情况及其与患者年龄和抗生素病史的关联.
- 了解肠道防御成熟和抗生素管理的影响.
主要方法:
- 对6256种儿科便培养物的分析.
- 根据阳性结果对结果进行分类 (单个与多个阳性).
- 阳性率与患者年龄和先前抗生素暴露的相关性.
主要成果:
- 在儿科便培养中,整体阳性率为11.4%.
- 阳性率随着患者年龄的增加而下降.
- 多重阳性培养 (0.4%) 仅在≤3.1岁儿童中发现.
- 所有具有多阳性培养的儿童都有抗生素使用史.
结论:
- 儿童的肠道防御机制随着年龄的增长而成熟.
- 儿童早期的抗生素暴露与多阳性便培养的风险增加有关.
- 谨慎的抗生素管理在幼儿时期至关重要,以防止肠道疾病和感染.
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