在多发性硬化症中解开微观结构和宏观结构的大脑年龄动态.
Xinjie Chen1,2,3, Po-Jui Lu1,2,3, Mario Ocampo-Pineda1,2,3
1Department of Biomedical Engineering, Translational Imaging in Neurology (ThINk) Basel, Faculty of Medicine, University Hospital Basel and University of Basel, Switzerland.
Neurology(R) neuroimmunology & neuroinflammation
|August 19, 2025
概括
定量核磁共振 (qMRI) 与传统核磁共振相结合,改善了多发性硬化症 (MS) 中大脑年龄的预测. 这种大脑预测的年龄差异 (大脑-PAD) 可以追踪多发性硬化症的进展,残疾和神经炎症.
科学领域:
- 神经成像是一种神经成像.
- 生物标志物 生物标志物
- 神经退行发生神经退行.
背景情况:
- 多发性硬化症 (MS) 涉及由疾病病理和衰老影响的神经退行.
- 传统的MRI显示结构变化,而定量MRI (qMRI) 测量微观结构变化.
- 结合MRI技术可以澄清MS残疾中的衰老-病理相互作用.
研究的目的:
- 评估qMRI在预测MS中大脑年龄差异 (大脑-PAD) 的附加值.
- 研究大脑-PAD,临床残疾和神经炎症生物标志物之间的关联.
- 为了确定集成的MRI模型是否能比单独的形态测量或qMRI更好地预测大脑年龄.
主要方法:
- 分析了来自1353名多发性硬化患者和3462名健康对照 (HC) 的横截面和纵向形态测量数据.
- 分析了来自169名多发性硬化症患者和378名高血压患者的横截面qMRI数据.
- 使用机器学习模型从形态学和qMRI数据估计大脑PAD;与临床和生物标志物数据的关联被评估.
主要成果:
- 综合形态测量和qMRI模型产生了最好的大脑年龄预测性能 (平均绝对误差:5.73).
- 基于形态学的大脑-PAD与残疾相关,神经丝光链和状纤维酸性蛋白质.
- 基于qMRI的脑PAD与白质病变数量和偏磁边缘病变体积相关.
结论:
- 整合qMRI提高了MS中大脑年龄预测的准确性.
- 从集成的MRI中获得的大脑PAD作为一个有价值的成像生物标志物.
- 这种方法可以量化MS相关的衰老,并监测疾病进展,残疾和神经炎症.
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