自我报告的对癌症治疗的坚持:对非坚持-癌症测量主观范围的领域的开发和验证
Yashasvini Sampathkumar1, Corrine I Voils2,3, Gina L Mazza4
1Memorial Sloan Kettering Cancer Center, New York, NY.
JCO oncology practice
|August 19, 2025
概括
剂量-不遵守-癌症工具有效地测量了各种癌症患者自我报告的不遵守. 这种经过验证的工具有助于理解癌症护理中的药物坚持挑战.
科学领域:
- 在瘤学瘤学.
- 医疗保健服务研究 医疗服务研究
- 患者报告的结果
背景情况:
- 癌症患者管理复杂的药物治疗方案,使用不同的时间表和剂量设置.
- 药物坚持对于治疗疗效至关重要,但在这个人群中具有挑战性.
- 现有的坚持措施可能无法捕捉癌症治疗坚持的细微差别.
研究的目的:
- 修改和评估癌症患者的主观不遵守范围 (DOSE-Nonadherence) 测量范围.
- 为了评估调整的措施的有效性,称为DOSE-不遵守-癌症,在异质的癌症群体中.
- 为测量自我报告的癌症治疗不遵守提供可靠的工具.
主要方法:
- 用患者输入和采访来代改进剂量-不坚持措施.
- 纳入药物管理设置 (家庭,诊所或两者) 的分支逻辑.
- 评估在设定特定参考期内自我报告的遵守情况,并与诊所所用药物的图表数据进行比较.
主要成果:
- 73名不同癌症患者 (86%为女性,44%年龄≥60岁) 完成了这项措施.
- 报告的不遵守率为诊所药物的26%,家庭药物的24%.
- 对临床药物的自我报告和图表抽象的坚持之间观察到很高的一致性 (96%).
结论:
- 剂量-不遵守-癌症测量是评估癌症患者不遵守的有效工具.
- 该措施适用于接受广泛的全身癌症治疗的患者.
- 这种经过验证的工具可以提高对癌症治疗坚持性的理解和管理.
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